At familysearch we’ve been working on a standard tool set for front-end developers to be amazingly productive/happy/awesome in. We settled on Node.js and have recently launched it in production. It is performing fantastically and we are falling in love.
If you’d like to work with Node.js and you’d like to do it at familysearch, give a holler to schlegel “at” familysearch dot org. Then we can tell you about all the other cool stuff we’re doing.
An excellent article from Louis Rosenfeld: Stop Redesigning And Start Tuning Your Site Instead. You and your key stakeholders need to read this.